Description
Product Characteristics:
Aliases: 52 kDa ribonucleoprotein autoantigen Ro/SS-A antibody, 52 kDa Ro protein antibody, 52kD Ro/SSA autoantigen antibody, Autoantigen Ro/SSA, 52-KD antibody, E3 ubiquitin-protein ligase TRIM21 antibody, RING finger protein 81 antibody, RNF81 antibody, Ro 52 antibody, Ro(SS-A) antibody, Ro52 antibody, RO52_HUMAN antibody, Sicca syndrome antigen A antibody, Sjoegren syndrome type A antigen antibody, Sjogren syndrome antigen A1 antibody, Sjogren syndrome type A antigen antibody, SS-A antibody, SSA antibody, SSA1: Sjogren syndrome antigen A1 (52 kDa ribonucleoprotein autoantigen SS-A/Ro) antibody, TRIM21 antibody, Tripartite motif protein TRIM21 antibody, Tripartite motif-containing 21 antibody, Tripartite motif-containing protein 21 antibody
Target Information: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]